Detalhe da pesquisa
1.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 184(18): 4651-4668.e25, 2021 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34450028
2.
Ticks Resist Skin Commensals with Immune Factor of Bacterial Origin.
Cell
; 183(6): 1562-1571.e12, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33306955
3.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 187(6): 1565-1566, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38490183
4.
Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product.
J Am Chem Soc
; 139(7): 2541-2544, 2017 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28170244
5.
Asymmetric Hydrogen Bonding Catalysis for the Synthesis of Dihydroquinazoline-Containing Antiviral, Letermovir.
J Am Chem Soc
; 139(31): 10637-10640, 2017 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28737937
6.
Unusual (+/-)-electrospray ionization induced fragmentation: Structural elucidation of an in-process synthetic intermediate of doravirine (MK-1439) using liquid chromatography/high-resolution tandem mass spectrometry and two-dimensional nuclear magnetic resonance.
Rapid Commun Mass Spectrom
; 31(8): 719-727, 2017 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28171682
7.
Identifying binding hot spots on protein surfaces by mixed-solvent molecular dynamics: HIV-1 protease as a test case.
Biopolymers
; 105(1): 21-34, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26385317
8.
Protein flexibility in docking and surface mapping.
Q Rev Biophys
; 45(3): 301-43, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22569329
9.
Parameter choice matters: validating probe parameters for use in mixed-solvent simulations.
J Chem Inf Model
; 54(8): 2190-9, 2014 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25058662
10.
Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases.
J Med Chem
; 67(7): 5758-5782, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38511649
11.
Improving protocols for protein mapping through proper comparison to crystallography data.
J Chem Inf Model
; 53(2): 391-402, 2013 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23327200
12.
CD98hc is a target for brain delivery of biotherapeutics.
Nat Commun
; 14(1): 5053, 2023 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37598178
13.
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
J Med Chem
; 65(24): 16290-16312, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36469401
14.
A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins.
Science
; 376(6599): 1321-1327, 2022 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35709255
15.
Binding to the open conformation of HIV-1 protease.
Proteins
; 79(7): 2282-90, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21604303
16.
Full protein flexibility is essential for proper hot-spot mapping.
J Am Chem Soc
; 133(2): 200-2, 2011 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21158470
17.
CSAR benchmark exercise of 2010: selection of the protein-ligand complexes.
J Chem Inf Model
; 51(9): 2036-46, 2011 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21728306
18.
Clarifying allosteric control of flap conformations in the 1TW7 crystal structure of HIV-1 protease.
Proteins
; 74(4): 872-80, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18704936
19.
Ramachandran-type plots for glycosidic linkages: Examples from molecular dynamic simulations using the Glycam06 force field.
J Comput Chem
; 30(6): 910-21, 2009 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-18785152
20.
Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevymis™ (letermovir).
Chem Sci
; 9(34): 6922-6927, 2018 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30210766